Chemo-Radiation With Cisplatin Advocated For Women With Stage IIIB Cervical Cancer

In the article "Chemo-radiation With Cisplatin Advocated for Women with Stage IIIB Cervical Cancer," Marilynn Larkin (2018), explores Indian studies claiming that optimal radiation and cisplatin enhances survival for women with stage IIIB cervical cancer more than radiation treatment. The article asserts that "cervical cancer is one of the common cancers in women in the developing world" (Larkin, 2018 Para 2). Besides, most cancers are diagnosed in advanced stages, which are correlated with cachexia, malnutrition, and anemia (Larkin, 2018). Consequently, cancers diagnosed at a superior stage results in poor outcome and compliance since factors such as anemia and malnutrition interfere with radiation treatment.

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Various researchers have dedicated much of their time and resources in understanding how the cancer cells develop and the factors that increase its development. Besides, their reaction with chemo treatment has been assessed. This condition has been attributed to the number o women who survive from once they have been diagnosed with the disease. Several experiments have been conducted in the article with the primary aim of establishing the connection between the various genes. In these studies, the impacts of the cells have been assessed and their impacts on the clinical stage, survival of the cancer cells, age, postmenstrual status, and menarche age established (Paice, & Ferrell, 2011). These studies have formed the basis of the research study and have significantly impacted on the conclusions of the research study.

Larkin (2018) highlights a study conducted by Dr, Mahantshetty among 850 women with FIGO stage IIIB squamous cell carcinoma of the uterine cervix in Mumbai. The participants of the study received either radiation (RT) alone or "concurrent cisplatin chemotherapy and radiation (CT-RT)" (Larkin, 2018 Para 5). The conclusions of the investigation designated that there was a 5-year disease-free survival in CT-RT (52.3%) than in RT (43.8%) (Larkin, 2018). The findings also portrayed a higher five-year overall survival in the CT-RT than in RT. According to Larkin (2018), the adjustments for tumor size, age, and other covariates also showed that CT-RT is considerably better than RT for disease-free and overall survival. As a consequence, Dr. Mahantshetty concluded that cisplatin-based chemo-radiation provides significantly better outcomes for women (Larkin, 2018).

Cancer is usually thought of as a fatal event with only a set amount of time to live. Everyday functions become hard as the body grows weak and cancer spreads. Dealing with cancer is a constant battle that no one should have to go through. The outcome can be devastating and take a toll on families. On a positive note, scientists are coming up with new and improved ways of limiting the spread of cancer as well as destroying the source as a whole. New advances in radionuclide therapy are helping fight the pain that prostate cancer inflicts on the body. Radio particles called radionuclides track the sites of increased bone turnover, which is usually an indication of bone metastases locations. Radium-223dichloride, a newly introduced radiopharmaceutical, uses high-energy alpha particles to bind to the newly formed bone stoma and destroys cells by breaking strands of DNA. The DNA becomes un-repairable and eventually eradicates the damaged cell (Paice, & Ferrell, 2011).

The research in this study can have various nursing implications. It can be used as a benchmark for further investigations designed at exploring the best health outcomes. The study also shows a survival advantage to the use of chemo-radiation over radiation alone. Thus, chemo-radiation could be used to prevent deaths and increase survival among women with cervical cancer.

References

Larkin, M. (2018). Chemo-radiation With Cisplatin Advocated for Women with Stage IIIB Cervical Cancer. Oncology learning network. Oncol2018.

Paice, J. A., & Ferrell, B. (May 01, 2011). The management of cancer pain. Ca: a Cancer Journal for Clinicians, 61, 3, 157-182.