DNA Nanobots: A New Hope for Cancer Treatment - Essay Sample

Introduction

For a long time, cancer has proven to be a considerable concern for public healthcare. Researchers are, therefore, looking for the best treatments nondiagnostic procedures that have limited side effects and those that can meet the challenges posed by the disease. According to Devasena, Brindha, and Thiruchelvi, (2018), one new technology that is likely to help with this medical concern is the DNA nanobots. This is the new technique that will be used for cancer treatment. From a global perspective, cancer has proven to be a burden in many countries and, in particular, the developing countries. Concern for cancer seems to be increasing with the poor prognosis that is common in developing countries; these are sequences that are rarely seen in developed countries. With several cases, cancer mortality and incidence, there is a significant rate variability that is seen with cancer that exists across different countries. Da Silva Luz et al. (2016) did the other research, claims that Nanorobotics will prove to be the most effective system in the drug delivery and the systems for the overall treatment of cancer. As one of these significant advancements has been realized in the late part of the 2010s, nanomedicine has progressively incorporated the different aspects of science and technology. Martel and Mohammadi (2016) analyze this method and stated that it should be used to switch between a magnetic tactic and aerotactic methods. It shows how the nanorobots are used to shrink tumors or cancer by cutting their blood supply off to reduce the chances of survival. This technology advocate for the development of a full autonomous DNA system that is precisely designed for cancer therapy. It is a technology backed with different institutes and will be the center of focus in the future for one of the biggest concerns in modern history.

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Studies have also shown that the impact that cancer has had on the social perspectives of cancer is a great concern in countries having different health systems and are socially distinct. Developed countries have increased their awareness of the ongoing social inequalities that affect the public health car. Various strategies and policies are implemented to help solve the situation. The most applicable case in this scenario is in Europe, where there have been numerous strategies and policies that are being implemented to reduce the occurrences of the disease. Recent reviews have also been emphasizing the existing knowledge about effective policies and interventions that can be used to curb sexual iniquities (Martel and Mohammadi, 2016). Nonetheless, they have proven to be less robust, especially when it comes to the design of the intervention and the most appropriate strategies to be used. The existing disparities in health care and use the summation of different countries in representing the challenges from the social, economic, environmental, and political factors.

Over the last ten years, there have been major advancements in cancer treatment and management. Since it is not possible to work with the available non-oncologist in Keeping up with the latest development in the field of oncology, games have been seen in different areas of treatment in recent years. This also resulted in a colossal shift in the paralegal paradigm of treatment. An example is the use of therapy in adjuvants breast cancer treatment as well as the use of mono clinical antibiotics with chemotherapy and without chemotherapy.

Various experts in the field of DNA have developed this technology over the past two decades through analyzing the atomic scale manufacturing while also building on the existing conditions. More complex structures and components of the DNA structures that can fold to form different shapes and sizes at different scales that are more than one thousand times smaller than the width of the human hair. The Revolution of computer and electronic medicine have ensured that this technology comes faster than anticipated (Martel, and Mohammadi, 2016). It is a project that is likely going to be better than the chemotherapy that is used today in treating cancer.

Nanomedicine is one of the new branches of medicine that is seeking to integrate components of nanotechnology while opening up new avenues of treatment, such as making minuscule nanoparticles that are part of the diagnosis and treatment of difficult and complex diseases such as cancer. Up to this time, the existing challenge is the advancement of nanomedicine that has proven to be difficult as scientists are all geared towards designing a more controlled and robots that would actively seek and destroy the cancerous tumors while at the same time not harming the human cells (Rosenblum et al., 2018). The ability to work with the cancerous cells and separated from the human cells is what is proven to be difficult because some of the cancer cells are within complex cells that cannot be easily separated to come close to the cancer cells.

Various teams of researchers have managed to overcome this problem through the use of a simple strategy that selectively strives to stuff out the tumor surrounding the cancer cells. This is a work that was initiated more than half a decade ago with the end CNST researchers that wanted to cut off the tumor blood supply through the introduction of coagulation through the use of hydroponic efficacy (Tyagi et al., 2016). This procedure is also safe and in an application for the vision implemented in the solid tumors and DNA-based nanocarriers that have programmable Nonrobotic systems. This branch of medicine can be easily programmed in order to transport molecular payloads while posing the on-site tumor blood supply blockage. When this luggage is initiated, it leads to the death of tissues that eventually shrinks the tumor.

The nanorobots can sometimes be programmed in a way that they transport molecular payloads that are causing tumor blood supply blockage on to the site and, therefore, the primary source of rescue in the new cancer progress. To perform this complicated study, the scientists decided to take advantage of the tumor models on a mouse and decided to inject the mouse with cancer cells from the human cells to induce aggressive tumor growth. Once the tumor had grown enough, the Nanorobotics is deployed to rescue and to lock the blood supply into the cells. All of the nanorobots come from rectangular DNA origin, which is predicted to produce better results. Thrombin is a crucial blood clotting enzyme that is found on the surface.

Thrombin blocks the blood flow to the tumor by plotting the blood in the vessels that are responsible for the tumor growth, thereby causing a mini heart attack to the tumor leading to its death (Sharma, Kumar, and Ambati, 2020). An average of 4 molecules of thrombin are used, and they are attached to the DNA scaffold. Flat sheet is made up of dead like a sheet of paper and made into a hollow tube then injected into the mouse so that it can travel through the bloodstream towards the tumor. One of the key issues is used in the nanorobot is that it only attacks the Cancer cell as it has a unique payload surface. The DNA targets explicitly nucleoli made of the high amount of tumor endothelial cells that are not anywhere within the healthy cells surface. One of the most concerning issues that were raised during this test was whether nanorobots was safe and effective when used in shrinking tumors. They proved to be safe, and in art immunological e when used on normal mice and also used in mice and smaller animals and large ones where, they were showing detectable changes in the normal blood cells. Nanorobotics is, therefore, for normal tissues when used with large animals and therefore, can be used to humans.

References

Devasena, U., Brindha, P., & Thiruchelvi, R. (2018). A review of DNA nanobots-a new technique for cancer treatment. Asian J Pharm Clin Res, 11(6), 61-64. DOI:10.22159/ajpcr. 2018.v11i6.25015

Da Silva Luz, G. V., Barros, K. V. G., de Araujo, F. V. C., da Silva, G. B., da Silva, P. A. F., Condori, R. C. I., & Mattos, L. (2016). Nanorobotics in drug delivery systems for treatment of cancer: a review. J Mat Sci Eng A, 6, 167-180. DOI: 10.17265/2161-6213/2016.5-6.005

Devasena, U., Brindha, P., & Thiruchelvi, R. (2018). A review of DNA nanobots-a new technique for cancer treatment. Asian J Pharm Clin Res, 11(6), 61-64. DOI:10.22159/ajpcr. 2018.v11i6.25015

Martel, S., & Mohammadi, M. (2016). Switching between magnetotactic and aerotactic displacement controls to enhance the efficacy of MC-1 magneto-aerotactic bacteria as cancer-fighting nanorobots. Micromachines, 7(6), 97. DOI:10.3390/mi7060097

Rosenblum, D., Joshi, N., Tao, W., Karp, J. M., & Peer, D. (2018). Progress and challenges towards targeted delivery of cancer therapeutics. Nature Communications, 9(1), 1-12. DOI:10.1038/s41467-018-03705-y

Sharma, A., Kumar, P., & Ambasta, R. K. (2020). Cancer-Fighting SiRNA-RRM2 loaded nanorobots. Pharmaceutical Nanotechnology. DOI:10.2174/2211738508666200128120142

Tyagi, N., Arora, S., Deshmukh, S. K., Singh, S., Marimuthu, S., & Singh, A. P. (2016). Exploiting nanotechnology for the development of microRNA-based cancer therapeutics. Journal of Biomedical Nanotechnology, 12(1), 28-42. DOI:10.1166/jbn.2016.2172